"The Freezer/Mill® programmable cryogenic grinder pulverizes through the toughest samples at cryogenic temperatures. Samples are placed in a vial and immersed in a self-contained insulated liquid nitrogen (LN2) tub, reaching cryogenic temperatures in minutes, where they are then pulverized with a magnetically driven impactor. The closed grinding vial impactor prevents sample cross-contamination. The single grinding and cooling chamber allows you to pre-cool and grind two sets of samples simultaneously.

Grind temperature sensitive samples while maintaining constant temperature, as the sample never leaves the enclosed liquid nitrogen bath. Enhanced safety features include a liquid nitrogen sensor and lid interlock. If the lid is opened while in process, grinding will stop. Auto-fill system is available for automated liquid nitrogen filling.

The large, high-resolution touch screen controls all parameters of the run. Store up to 20 user-defined grinding programs for quick and easy recall. The user-friendly interface allows you to view training videos, user manual, and run history, which can be transferred to a computer using a thumb drive.

Purchase liquid nitrogen, extractor, and sample vials separately."

The CG-400 Freezer/Mill® is designed to quickly and effectively grind challenging materials by cooling them to cryogenic temperatures and pulverizing them into a fine powder—without heat damage or cross-contamination. Whether you’re working with biological, pharmaceutical, or food samples, this powerful mill ensures sample integrity for accurate, repeatable results. The large cryogenic mill accommodates sample sizes ranging from 0.1 to 50 grams.

Typical applications include: DNA/RNA extraction, forensic/drug testing, RoHS/WEEE, consumer product testing, food safety, materials research & medical research.

Typical samples include: animal tissue, plastic and polymers, yeast, pharmaceuticals, food products, electronic components, textiles, hair, teeth, bones, plant tissue such as cannabis, seeds, leaves and roots.

The Cole-Parmer® SamplePrep CG-400 Freezer/Mill preserves sample integrity by maintaining cryogenic temperatures with continuous liquid nitrogen immersion, preventing degradation of heat-sensitive compounds like metabolites and isomers. Since the vial is securely closed the integrity of its contents is maintained, hazardous or critical samples are easily controlled, and cross-sample contamination is eliminated.

The Freezer/Mill accommodates samples ranging from 0.1 to 50 grams with multiple vial options for different sample sizes, and works with various vial materials including polycarbonate, stainless steel, and low-chrome steel.

Our proven technology uses a dual electromagnetic grinding chamber that rapidly drives a steel impactor back and forth against the two end plugs of the sample vial and pre-cools and pulverizes samples in one seamless step. An optional auto-fill system is available to automate liquid nitrogen refills for added convenience.

The CG-400 is built for safety and longevity. The liquid nitrogen sensor prevents damage by ensuring proper cooling during operation, shutting down the mill if the liquid nitrogen level is too low. The Cole-Parmer SamplePrep Freezer/Mill is designed for use in an open, well-ventilated workspace to avoid condensation-related issues. Cryogenic gloves and safety gear are recommended for safe handling.

Effective September 2023, the Spex SamplePrep 6875 Freeer/Mill® has been rebranded to Cole-Parmer® SamplePrep under model number CG-400 Freezer/Mill®. All the same great features and specification with a new look.